ABSTRACT
The proceedings contain 123 papers. The topics discussed include: national study on the risks of COVID-19 for pediatric renal transplant recipients;evaluation of a creative photography workshop for children and young people following a diagnosis of PIMS-TS;reducing blood product usage through technology in transplantation;pharmacokinetic modelling of different tacrolimus formulations in children and adolescents;pediatric laparoscopic splenectomy: a single center 11 years' experience;our people: pursuing positivity in the pandemic - 'pause, power up, push on';delivering digital learning packages to address allied health professionals' skill gaps in research;building Bertie bowel: designing an immersive simulation experience for pediatric radiology teams managing intussusception;development of OctiPAT: a patient-facing mobile and web-based application to provide higher quality, patient-focused, multidisciplinary care to a complex patient cohort;and implementing Speech@Home into clinical practice using a quality improvement (QI) methodology.
ABSTRACT
Vaccines are powerful tools for preventing infection or disease from the infectious pathogens they target, but they may induce additional effects unrelated to the intended targets. Similar to other pharmaceutical products, vaccines may cause side effects, but tolerance to these is extremely low due to the use of vaccines in healthy people, particularly children. Redness, swelling or soreness at the site of injection are common for many vaccines under the term of reactogenicity. High fever can be present at a rate of 1/100 to /100 000 as can fever-induced convulsions from vaccines such as measles, mumps or rubella. Rotavirus vaccines are suspected to be associated with intussusception in about 1/100 000 first doses. Allergic reactions are in the same range. The massive H1N1 vaccination in the world has also been potentially associated with an increase in narcolepsia in patients with a risk allele. More recently, the SARS-CoV-2 vaccine ChAdOx1 nCov-19 have been found to cause a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia in very few people. Consequently, vaccines must undergo vigorous assessment before and after licensure to minimize safety concerns. Potential safety concerns should be identified as early as possible during the development for vaccines. In this CEC, along with courses, the attendees will have to work in small groups on real case studies associating non-clinical development and regulatory strategies. Copyright © 2022 Elsevier B.V.